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Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normality - PubMed

Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normality - PubMed

Desc: There are numerous mental health threats associated with the current pandemic and subsequent restrictions. Child and adolescent psychiatrists must ensure continuity of care during all phases of the pandemic. COVID-19-associated mental health risks will disproportionately hit children and adolescents …

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International classification of sleep disorders-third edition: highlights and modifications - PubMed

International classification of sleep disorders-third edition: highlights and modifications - PubMed

Desc: The recently released third edition of the International Classification of Sleep Disorders (ICSD) is a fully revised version of the American Academy of Sleep Medicine's manual of sleep disorders nosology, published in cooperation with international sleep societies. It is the key reference work for t …

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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission - PubMed

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission - PubMed

Desc: Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large …

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False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care - PubMed

False-positive results released by direct-to-consumer genetic tests highlight the importance of clinical confirmation testing for appropriate patient care - PubMed

Desc: Our results demonstrate the importance of confirming DTC raw data variants in a clinical laboratory that is well versed in both complex variant detection and classification.

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders - PubMed

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders - PubMed

Desc: C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-w …

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Emotion Theory and Research: Highlights, Unanswered Questions, and Emerging Issues

Emotion Theory and Research: Highlights, Unanswered Questions, and Emerging Issues

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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Desc: A.P.P was supported by NIH/NINDS R25NS065743. I.T. was supported by a Human Frontier Science Program fellowship and a Rothschild fellowship.

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› Url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123637/

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Student nurses' knowledge and attitudes towards domestic violence: results of survey highlight need for continued attention to undergraduate curriculum - PubMed

Student nurses' knowledge and attitudes towards domestic violence: results of survey highlight need for continued attention to undergraduate curriculum - PubMed

Desc: Continued effort is required to address domestic violence in undergraduate nursing education so that nursing graduates understand the association between violence exposure and poor health and are able to assess exposure and respond appropriately in the clinical environment.

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Physical Activity Promotion: Highlights from the 2018 Physical Activity Guidelines Advisory Committee Systematic Review - PubMed

Physical Activity Promotion: Highlights from the 2018 Physical Activity Guidelines Advisory Committee Systematic Review - PubMed

Desc: A promising number of interventions with demonstrated effectiveness were identified. Future recommendations for research include investigating the most useful methods for disseminating them to real-world settings; incorporating more diverse population subgroups, including vulnerable and underreprese …

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Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza - PubMed

Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza - PubMed

Desc: The genus Oryza is a model system for the study of molecular evolution over time scales ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the Oryza species tree, we show that despite few large-scale chromosomal rearrangements rapid species diversification is mirror …

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Vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis - PubMed

Vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis - PubMed

Desc: In this study, we sought to find novel bacterial and metabolic hallmarks for bacterial vaginosis (BV). We studied the vaginal microbiome and metabolome of vaginal fluids from BV-affected patients (n = 43) and healthy controls (n = 37) by means of an integrated approach based on quantitative polymera …

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Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care - PubMed

Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care - PubMed

Desc: Racial and ethnic disparities in health care are known to reflect access to care and other issues that arise from differing socioeconomic conditions. There is, however, increasing evidence that even after such differences are accounted for, race and ethnicity remain significant predictors of the qua …

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Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation - PubMed

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation - PubMed

Desc: Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated inflammatory response. Autoimmune diseases, including Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus, c …

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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations - PubMed

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations - PubMed

Desc: Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 indi …

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Genome sequencing highlights the dynamic early history of dogs - PubMed

Genome sequencing highlights the dynamic early history of dogs - PubMed

Desc: To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden jack …

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vigiGrade: a tool to identify well-documented individual case reports and highlight systematic data quality issues - PubMed

vigiGrade: a tool to identify well-documented individual case reports and highlight systematic data quality issues - PubMed

Desc: Overall, only one report in eight provides the desired level of information, but much higher proportions are observed for individual countries. Physicians and e-reporting tools also generate greater proportions of well-documented reports overall. Reports from consumers/non-health professionals in sp …

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Improving Students' Learning With Effective Learning Techniques: Promising Directions From Cognitive and Educational Psychology - PubMed

Improving Students' Learning With Effective Learning Techniques: Promising Directions From Cognitive and Educational Psychology - PubMed

Desc: Many students are being left behind by an educational system that some people believe is in crisis. Improving educational outcomes will require efforts on many fronts, but a central premise of this monograph is that one part of a solution involves helping students to better regulate their learning t …

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